Mixture of 2.5% Phenylephrine and 0.75% Tropicamide for Pupil Dilatation

Adisak Trinavarat M.D.

Auengporn Pituksung B.Sc.

Suthipol Udompunturak M.Sc.s

ABSTRACT Objective : To evaluate an efficacy and adverse effects of the eyedrop made from 10% phenylephrine and 1% tropicamide in the ratio of 1:3 for pupil dilatation.

Methods : The mixture was instilled every 15 minutes, no more than 4 times to get the pupils dilated to 8 mm in diameter. The study was conducted in 76 eyes of 39 patients with the pupil diameters of 2.18 ± 0.56 (1-3) mm.

Results : Fifty-nine eyes (77.6%) were dilated to 8 mm by 2.8 ± 0.7 (2-4) instillations. In the remaining eyes, pupil diameters were 6.56 ± 0.73 (5-7) mm after 4 times of application. The pupils were dilated to 7 mm in 70 eyes (92.1%). No significant changes in blood pressure and pulse rate were found in all patients.

Conclusions : Mixture of 2.5% phenylephrine and 0.75% tropicamide can be used effectively and safely as a mydriatic drug.

Thai J ophthalmol 1999 ; January-June 13(1) : 11-15.

Key word : Pupil dilatation (mydriasis) phenylephrine mydriatices.-