Blindness from Leptomeningeal Metastasis (LM) : A Case Report and Review

Sopit Samapanpong M.D.,
Praween Kanjanapitak M.D.

ABSTRACT : The sudden onset of blindness in adults, with or without history of malignancy should raised the possibility of meningeal carcinomatosis. The actual mechanism by which blindness occurs is problbly a combination of tumour cuffing around optic nerve, direct infiltration and chronic papilledema. We reported a case of blindness from leptomeningeal metastasis from lung cancer. A 55 years old man presented with weakness of right thigh and decreased vision. Investigation revealed of lung infiltrates and CT brain reported hydrocephalus. Malignant cells was demonstrated in CSF nd lung biopsy showed bronchioloalveolar carcinoma.

Thai J Ophthalmol 2001 : January-June 15(1) : 53-62

Key words : Leptomenigeal metastasis. Bronchioloalveolar carcinoma, Blindness