เผยแพร่ผลงานวิจัยของจักษุแพทย์ไทย

ในจดหมายข่าว Academy Express

Academy Express เป็นจดหมายข่าว อิเล็กทรอนิกส์ ที่จัดทำโดย American Academy of Ophthalmology ส่งทาง email ทุกสัปดาห์ ถึงสมาชิกของ 19 องค์กร วิชาชีพทางจักษุวิทยาใน Asia Pacific region รวมทั้ง RCOPT ราชวิทยาลัยฯเชิญชวนสมาชิกจักษุแพทย์ ติดตาม ผลงานวิจัยของจักษุแพทย์ไทย ในคอลัมน์ ASIA PACIFIC JOURNAL STUDIES ในจดหมายข่าวดังกล่าว

ท่านสมาชิกจักษุแพทย์ที่มีผลงานวิจัยใหม่ในวารสารวิชาการทางจักษุวิทยาที่เป็น indexed journal ส่งผลงานเพื่อเผยแพร่ใน Academy Express ฉบับต่อไปได้ที่ yyosanan@gmail.com หรือ admin@rcopt.org

Academy Express Asia Pacific Edition ฉบับวันที่ 30 Mar 2024

Certain Variables and Models May. Be Able to Predict Post-ICRS Implantation Outcomes

Investigators conducted a retrospective chart review of 230 eyes with keratoconus

to identify predictive factors and develop predictive models for visual acuity changes

following intracorneal ring segment implantation. Data from one set of eyes were used to explore the correlation between certain variables and 6-month postoperative changes in uncorrected and corrected distance visual acuity ( ΔUDVA and ΔCDVA). The only variable that showed a strong correlation with ACDVA was preoperative corrected distance visual

acuity; no variables had a strong correlation with UDVA. The proposed predictive model for AUDVA found that poorer preoperative UDVA and lower front mean keratometry values led to greater UDVA gains. PLOS One, February 2024

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288181

Academy Express Asia Pacific Edition ฉบับวันที่ 22 Mar 2024

Only 30 Minutes of Monocular Occlusion May. Be Needed for Patients with Intermittent Exotropia

In this prospective cohort study, researchers assessed the optimal duration of monocular

occlusion to eliminate the fusion effect in patients with intermittent exotropia (N = 40). Deviation angles were measured both at distance (6 m) and near fixation (0.33 m) before and after 30, 60, and 90 minutes of monocular occlusion. Prior to occlusion, mean deviation angles were 27.8 PD at distance and 26.0 PD at near fixation. Following monocular occlusion, mean angles at distance were approximately 32.2, 32.9, and 32.6 PD at 30, 60, and 90 minutes, respectively; at near fixation, corresponding angles were 37.4, 39.8, and 39.5 PD, respectively. Given these findings, the authors conclude that 30 minutes of monocular occlusion is enough time to achieve the maximum deviation angle. Clinical Ophthalmology, January 2024

https://www.dovepress.com/optimal-duration-of-monocular-occlusion-to-eliminate-fusion-effect-in--peer-reviewed-fulltext-article-OPTH

Academy Express Asia Pacific Edition ฉบับวันที่ 15 Mar 2024

Good Long-Term Outcomes Are Seen with Epithelial Transplantations for LSCD

A 15-year retrospective systematic study compared the long-term outcomes of

cultivated limbal epithelial transplantation (CLET), simple limbal epithelial transplantation (SLET), and cultivated oral mucosal epithelial transplantation (COMET) for the treatment of 103 eyes (94 patients) with limbal stem cell deficiency (LSCD). Surgical success rates were 77.8% for SLET, 57.8% for COMET, and 45.5% for CLET; 7-year transplantation survival rates were 72.2%, 53.2%, and 50.0%, respectively. Significant risk factors for surgical failure

were Stevens-Johnson syndrome, Schirmer I test <5 mm, and the presence of

postoperative recurrent epithelial defects. The Ocular Surface, April 2024

https://www.sciencedirect.com/science/article/pii/S154201242400003X

Academy Express Asia Pacific Edition ฉบับวันที่ 8 Mar 2024

Benefits and Risks Are Noted with Combined Topical/Subconjunctival Anesthesia for Phacoemulsification

A double-blind, parallel, placebo-controlled, randomized trial compared the efficacy of

the combination of topical anesthesia plus subconjunctival anesthesia vs topical

anesthesia alone for phacoemulsification. One hundred seventy-six patients aged 240

years with diagnosed senile cataract received either topical anesthesia with 0.5%

tetracaine hydrochloride plus subconjunctival injection with 2% lidocaine or topical anesthesia plus placebo. The combination group exhibited a significantly greater reduction in immediate postoperative pain than the topical-alone group, with sustained pain reduction over 2 hours. However, the lidocaine injection itself was reported as painful, and there was an increased risk of subconjunctival hemorrhage associated with this intervention. BMC Ophthalmology, January 2024

https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-024-03284-1

Academy Express Asia Pacific Edition ฉบับวันที่ 23 Feb 2024

A Thai-Language Version of the Telehealth Usability Questionnaire Has Early Reliability Data

In this cross-sectional validation study, investigators developed and assessed a Thai-language version of the Telehealth Usability Questionnaire (T-TUQ). Two hundred and ten Thai participants were recruited from 3 specialty clinics: movement disorders, hematology, and general neurology. The questionnaire was translated from English to create the T-TUQ version and then underwent back translation and pilot cognitive interviews. The 5 T-TUQ

scales (ease of use, usefulness, reliability, effectiveness, and satisfaction) demonstrated good to excellent internal consistency and high mean usability. The authors conclude that the T-TUQ may be a reliable and valid instrument for evaluating the usability of telehealth programs in Thailand. International Journal of Telerehabilitation, December 2023

https://telerehab.pitt.edu/ojs/Telerehab/article/view/6577

Academy Express Asia Pacific Edition ฉบับวันที่ 16 Feb 2024

Success of Conjunctivo-Mullerectomy Correlates with Degree of Ptosis Severity

A prospective cohort study assessed the efficacy of conjunctivo-mullerectomy in 258 ptotic eyes (159 patients) with varying ptosis severities (determined by margin-to-reflex difference) as well as factors that could influence outcomes and complications of this procedure. At 3 months, surgical success rates for mild, moderate, and severe ptosis were 96.6%, 91.7%, and 83.5%, respectively. Eyes that underwent conjunctivo-mullerectomy plus tarsectomy had a higher risk of surgical failure than eyes that underwent conjunctivo- mullerectomy alone. Levator muscle function did not have an impact on surgical

success or failure. Scientific Reports, November 2023

https://www.nature.com/articles/s41598-023-46419-y

Academy Express Asia Pacific Edition ฉบับวันที่ 10 Feb 2024

Chicago Sky Blue Gel Aids in Identifying and Quantifying Demodex Mites

In this cross-sectional study, light microscopy was used on the eyelashes of 30 adults with suspected Demodex blepharitis to count the number of Demodex mites before and after applying Chicago Sky Blue (CSB) gel, a new staining product developed to make it easier to see Demodex mites. Mite counts were assessed by both an untrained and an experienced

investigator. Both the investigators recorded significantly higher median Demodex mite

counts after the CSB gel was applied. These findings suggest that CSB gel holds promise

as a diagnostic stain for identifying and quantifying Demodex mites. Peer, November 2023

http://rcopt.org/images/uploads/peerj-16378.pdf

Academy Express Asia Pacific Edition ฉบับวันที่ 3 Feb 2024

A Majority of Patients with Retained IOFBs Have Improved Vision After Treatment

This retrospective cohort study evaluated risk behaviors and visual outcomes in 161 patients (162 eyes) with retained intraocular foreign bodies (IOFBs) andexamined the predictive value of the Ocular Trauma Score (OTS) in determining visual outcomes. Ninety-three percent of patients were working males. The most common activity associated with injury was using a grass trimmer or mower. Following surgical and/or pharmacologic treatment, the percentage of eyes with vision worse than 20/400 decreased from 78% at baseline to

34% at the final visit. The OTS showed high predictive potential for final vision in eyes in

OTS categories 4 and 5 (better prognoses). Heliyon, October 2023

https://www.cell.com/heliyon/fulltext/S2405-8440(23)07848-9

Academy Express Asia Pacific Edition ฉบับวันที่ 26 Jan 2024

In Juvenile Open-Angle Glaucoma, Poor Vision Remains an Issue Even After Treatment

A retrospective multicenter study assessed the characteristics and treatment outcomes of 104 patients with juvenile open-angle glaucoma (JOAG). The mean age of JOAG onset was 24 years. Sixty-one percent of patients were male, and 92% of patients had bilateral disease. Patients were treated with either antiglaucoma medications or surgery; the most commonly performed surgical procedure was trabeculectomy with mitomycin-C. In the patients who

underwent trabeculectomy, only 46% achieved qualified success 10 years after surgery. Regardless of treatment, 15% of the study population eventually met the World Health Organization criteria for visual impairment and 21% met the criteria for blindness. Journal of Glaucoma, November 2023

https://journals.lww.com/glaucomajournal/fulltext/2023/11000/treatment_outcomes_for_juvenile_open_angle.10.aspx

Academy Express Asia Pacific Edition ฉบับวันที่ 19 Jan 2024

Primary Angle-Closure Disease Subtypes Have Wide Variations in 24-Hour IOP Patterns

In a prospective cohort study, 24-hour IOP patterns were evaluated in 59 eyes of 35 patients with chronic primary angle-closure disease (PACD). Patients were divided into 3 groups based on type of PACD: primary angle closure (PAC), primary angle-closure suspect (PACS), and primary angle-closure glaucoma (PACG). Peak, mean, and trough 24-hour IOP values and 24-hour IOP fluctuation (difference between peak and trough values) were compared among groups. Multivariable analysis found that PAC and PACG eyes showed significantly higher peak IOP and 24-hour IOP fluctuation values than PACS eyes. When combined PACS and PAC eyes were compared with PACG eyes, PACG eyes revealed significantly higher 24-hour IOP fluctuation. Journal of Glaucoma, October 2023

https://journals.lww.com/glaucomajournal/fulltext/2023/10000/twenty_four_hour_intraocular_pressure_in_chronic.10.aspx

Academy Express Asia Pacific Edition ฉบับวันที่ 12 Jan 2024

A Fluctuation Index May. Be Able to Predict Responses to Neovascular AMD Therapy

Using results from the TOWER cohort study, which assessed the effects of anti-VEGF injections in treatment-naive patients with neovascular AMD (nAMD) for a period of 1-3 years, the authors propose a new parameter called the Fluctuation Index (FI) that can be used to measure retinal fluid fluctuation during nAMD treatment. The FI was based on the sum of differences (decreased or increased) in 1 mm central subretinal thickness between each follow-up visit during months 3-24 of TOWER, divided by the total number of visit intervals. The FI values showed better correlation with visual outcomes than the traditional standard deviation of foveal thickness/CST. The presence of intraretinal fluid was predictive

of fluctuating macular thickness over the time period. Translational Vision Science & Technology, October 2023

https://tvst.arvojournals.org/article.aspx?articleid=2792887

Academy Express Asia Pacific Edition ฉบับวันที่ 5 Jan 2024

Different OCTA Devices Are Not Interchangeable for Measuring Capillary Density

A prospective study investigated whether there was agreement among 4 OCT angiography (OCTA) devices in radial peripapillary capillary (RPC) density measurements. The study included 48 eyes of 48 participants (19 with glaucoma, 15 with non-glaucomatous optic neuropathy, and 14 healthy controls). Each eye was scanned with the OCTA devices in a random sequence, and grayscale OCTA images from each device were analyzed for RPC density. The overall interclass correlation coefficient (ICC) was 0.31, indicating poor correlation among devices. Significant proportional biases were identified as well. The overall conclusion was that RPC density obtained from different OCTA devices varied and thus cannot be used interchangeably; therefore, a single OCTA device should be used to

monitor optic neuropathy in a specific patient population. Translational Vision Science & Technology, August 2023

https://tvst.arvojournals.org/article.aspx?articleid=2791384