Efficacy and Safety of Multiple Needle Revisions and 5-FU Injections in Over 14-month old Dysfunctio

Updated 2020-03-10 10:32:00

Manchima Makornwattana, MD. Department of Ophthalmology, Faculty of Medicine, Thammasat University
Objective: To evaluate efficacy and safety of multiple needle revisions and 5-FU injections in over 14-month old dysfunctional blebs in Thai patients. Methods: Eight eyes of 8 Thai patients who had surgically restored bleb function by using needle revision and 5-FU injection from one ophthalmologist, same technique in over 14-month old dysfunctional blebs in between January 2008 and April 2009 were enrolled, a retrospective study. The dysfunctional bleb was defined if the IOP less than 21 mmHg with anti-glaucoma medication or more than 21 mmHg with or without anti-glaucoma medication. The success of the needling revision was defined as absolute if the intraocular pressure (IOP) was < 21 mmHg without antiglaucoma medications. Bleb function was evaluated by slit-lamp biomicroscopic examination. Intraocular pressure measurement by applanation tonometry, morphology and degree of filtering bleb vascularization were evaluated and recorded. Intervention, either or both 5-FU or needling was performed when unsuccessful functioning bleb has been revealed to achieve target IOP less than 21 mmHg without antiglaucoma drugs. Results: Mean of needle revision times and 5- FU injections are 1.25 and 6.25 mg, respectively. There were 100% (8 cases) successes to achieve IOP less than 21 mmHg without anti-glaucoma medication for at least 3 months post-interventional. There was no report of serious complication or infection during and post-intervention. Conclusions: Needle revisions and 5-FU injections in over 14-month old dysfunctional blebs are simple, convenient, safe and effective in Thai patient.
Volume 4 No. 1 January-June 2009 ISSN 1905-2960
Category: Original Articles
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